PR Domain Containing Protein 12 (PRDM12)

PRDM12 is a member of the closely related PR-domain-containing zinc-finger family. PRDM12 therefore represents an attractive candidate tumour suppressor gene within the der CDR. Detailed mapping of the extent of the insertion revealed that the distal breakpoint had occurred within a 70 kb region containing the PRMD12 gene. Disruption of PRMD12 may account for the observed short survival of this patient and further support a role for this gene in the pathogenesis of CML patients with der deletions. Disruption of PRMD12 precipitated an aggressive phenotype in this patient is in keeping with the suggestion that this gene may behave as a classical tumour suppressor in cases of CML with deletion of der. The PRMD12 gene warrants further attention in order to elucidate its role in the pathogenesis of CML.