PR Domain Containing Protein 4 (PRDM4)

PRDM4 is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). PRDM4 encodes a deduced 796-amino acid protein that has a PR domain in its middle portion followed by 6 zinc finger motifs in the C terminus. An alternative mRNA species of approximately 7.0 kb was found specifically in ovary and testis, and another of approximately 3.4 kb was found at low levels in peripheral blood leukocytes, colon, ovary, testis, prostate, and spleen. PRDM4 mRNA levels were highly elevated in PC12 cells treated with NGF, suggesting a role for PRDM4 in the NGF signal transduction pathway.