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Артикул
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Наименование |
Производитель
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| DF16045 |
DF16045
PRDM8 Antibody
Источник (хозяин): кролик
Реактивность подтвержденная: человек, мышь
Валидировано для:
Производитель:Affinity
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Affinity |
PR Domain Containing Protein 8 (PRDM8)
Английские синонимы
PFM5; PR domain-containing protein 8
A family of PRDM proteins are similar to histone methyltransferases (HMTases) with SET domain in that they modulate different cellular processes, including transcriptional regulation, through chromatin modifying activities. In vitro HMTase assay and immunoblot analysis revealed that PRDM8 specifically methylates H3K9 of histones which indicates transcriptional repression activity of PRDM8.Direct recruitment of PRDM8 to the promoter mediated transcriptional repression and indicated no involvement of HDAC. Tissue blot analyses identified PRDM8 transcripts from brain and testis in adult mouse. PRDM8 repressed the expression of steroidogenic markers, p450c17c and LHR, which indicates its regulatory role in mouse testis development.
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