PX Domain Containing Protein 1 (PXDC1)

C6orf145 Contains 1 PX (phox homology) domain. The phox homology (PX) domain is a phosphoinositide-binding domain that is conserved from yeast to human. The PX domain is a bona fide protein interaction domain.  Interactions of Grd19p, Vam7p, Vps5p, Vps17p, and Ypt35p with members of the Yip1p family of proteins were detected consistently and were verified by in vitro binding assays. The N-terminal cytoplasmic domain of Yip1p and Yif1p mediates these interactions with PX domains. A mutation in the lipid-binding pocket of Ypt35p that reduces lipid binding markedly does not affect these PX domain protein interactions, arguing that lipid binding uses a different interaction surface than protein binding.