Patatin Like Phospholipase Domain Containing Protein 7 (PNPLA7)

Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli.By database analysis, followed by screening of human EST databases, Wilson et al. (2006) identified PNPLA7. The deduced 1,317-amino acid protein has a patatin-like domain, a predicted transmembrane domain, cyclic nucleotide binding sites, a glycosaminoglycan attachment site, 3 tyrosine kinase phosphorylation sites, and a cell attachment sequence. PNPLA7 shares approximately 60% sequence identity with PNPLA6. Quantitative RT-PCR analysis showed that PNPLA7 was predominantly expressed in prostate, pancreas, and adipose tissue.