Pellino Homolog 1 (PELI1)

Peli1 was required for TLR3-induced activation of IB kinase (IKK) and its """downstream""" target, transcription factor NF-B, but was dispensable for IKK–NF-B activation induced by several other TLRs and the interleukin 1 (IL-1) receptor. Notably, Peli1 bound to and ubiquitinated RIP1, a signaling molecule that mediates IKK activation induced by the TLR3 and TLR4 adaptor TRIF. Peli1 is a ubiquitin ligase needed for the transmission of TRIF-dependent TLR signals.Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping.