Peroxisomal Membrane Protein 34kDa (PMP34)

SLC25A17 is a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers.The deduced 307-amino acid protein has a calculated molecular mass of 34.5 kD and contains 6 membrane-spanning regions. Wylin et al. (1998) deduced the mouse sequence by database analysis and found that both the human and mouse proteins share 33% identity with the yeast protein. By RT-PCR, using primers specified for the mouse sequence, they identified a 233-bp transcript in human liver and in all rat and mouse tissues examined. By fluorescence microscopy of human hepatoma cells and mouse fibroblasts transfected with a plasmid encoding a fluorescence-tagged fusion protein, Wylin et al. (1998) found that the protein colocalizes with the dimeric peroxisomal thiolase.