Peroxisomal Membrane Protein 4 (PXMP4)

Pxmp4, which encodes a 24-kDa peroxisomal integral membrane protein of unknown function. Pxmp4 was originally isolated as a 24-kDa polypeptide from rat liver peroxisome membranes (36). As increased message for Pxmp4 is associated with the NOD allele that confers weaker NKT cell stimulatory capacity, one possibility is that Pxmp4 contributes to the biosynthesis of a nonstimulatory etherphospholipid ligand for CD1d. Pxmp4 may be a component in a fatty acid degradation pathway that catabolizes stimulatory CD1d ligands. Peroxisomes play a critical role in the - and
-oxidation of very long chain fatty acids. Pex19 associates with Pxmp4 during or immediately after its translation by free ribosomes. Peroxisomal membrane insertion of the Pxmp4-Pex19 complex is dependent on Pex3p.