Phosducin Like Protein (PDCL)

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. PDCL shares extensive amino acid sequence homology with phosducin (PDC), a phosphoprotein expressed in retina and pineal gland that inhibits several G protein-coupled signaling pathways by binding to the beta-gamma subunits of G proteins.The authors derived the complete PDCL coding sequence by aligning the genomic and EST sequences. The predicted 301-amino acid PDCL protein shows homology to areas of rat Pdc that contact G protein beta-gamma subunits. The N-terminal regions of human, rat, and Drosophila PDCL are highly homologous to each other, but show little homology to the N-terminal region of rat Pdc.