Pleckstrin Homology Domain Containing Family O, Member 2 (PLEKHO2)

PLEKHO2 Contains 1 PH domain. Pleckstrin homology (PH) domain family using homology based modelling as an extension of traditional sequence analysis techniques. Many of the PH domain containing proteins are found to participate in signalling cascades but there are also other classes of proteins such as cytoskeletal proteins (eg spectrin) that carry a PH domain. The PH domain family is very divergent at a sequence level, the average pairwise identity is below 20%. Despite this it is structurally very conserved with the core secondary structure superimposing well and almost all variation confined to the loops. Generall, one would need a higher identity between such small proteins to be confident about structural homology predictions and this remarkable structural conservation is one of the interesting features of this domain.