Post GPI Attachment To Proteins 3 (PGAP3)

The deduced 319-amino acid protein contains several transmembrane domains. CAB2 was ubiquitously expressed, with highest levels in adult thyroid and placenta and in all 4 fetal tissues examined. Fluorescence-tagged CAB2 accumulated in cytoplasmic vesicles in a transfected human breast cancer cell line.The human and mouse MGC9753 proteins contain 320 amino acids and share 85% amino acid identity. Both have an N-terminal signal peptide, followed by an extracellular 6-cysteine domain, 7 transmembrane domains, and an N-glycosylation site at asn40. Human MGC9753 shares 90.6% identity with the CAB2 protein reported by Nezu et al. (2002), which diverges in the central region and lacks transmembrane domain-3 due to a frameshift.