Potassium Channel Subfamily T, Member 1 (KCNT1)

KCNT1, The deduced 1,151-amino acid protein shares 94% identity with the rat Slack potassium channel subunit. RT-PCR detected moderate to high expression of KCNT1 in all tissues examined. Highest expression was detected in adult and fetal liver and brain, in spinal cord, and in most specific brain regions examined. Lowest expression was detected in skeletal muscle.Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions.