Potassium Channel Tetramerisation Domain Containing Protein 17 (KCTD17)

The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. KCTD17 (potassium channel tetramerisation domain containing 17) is a 321 amino acid protein that contains one BTB domain, suggesting a possible role as a transcriptional regulator. The gene encoding KCTD17 maps to chromosome 22, which contains over 500 genes. As the second smallest human chromosome, 22 contains a surprising variety of interesting genes, including Phelan-McDermid syndrome, neurofibromatosis type 2 and autism.