Potassium Channel Tetramerisation Domain Containing Protein 2 (KCTD2)

By sequencing clones obtained from a size-fractionated KG-1 myeloid leukemia cell line cDNA library, Nagase et al. (1996) cloned KCTD2, which they designated KIAA0176. The deduced protein contains 265 amino acids. Northern blot analysis detected KCTD2 in all human tissues and cell lines examined.K+ channel tetramerisation domain is the N-terminal, cytoplasmic tetramerisation domain (T1) of voltage-gated K+ channels.The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated potassium channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. This domain is found in a subset of a larger group of proteins that contain the BTB/POZ domain.