Potassium Voltage Gated Channel Shaker Related Subfamily, Member 10 (KCNA10)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. KCNA10 is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.