Potassium Voltage Gated Channel Shaw Related Subfamily, Member 2 (KCNC2)

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. KCNC2 belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.KCNC2 and KCNC3 genes are located on 19q13.3-q13.4. From the inheritance patterns of DNA restriction fragment length variants (RFLV) in recombinant inbred strains of mice, they placed the homologous loci on mouse chromosome 10.