Potassium Voltage Gated Channel Subfamily G, Member 3 (KCNG3)

Voltage-gated potassium channels play an essential role in controlling cellular excitability in the nervous system. These channels are multimeric proteins containing alpha subunits, which are directly responsible for channel activity, and gamma subunits, which modify the basic channel activity. Kv6.3 functions as a gamma subunit.Kv6.3 encodes a deduced 437-amino acid sequence with a predicted molecular mass of 49 kD. It shares 34% sequence identity with Kv6.2 and 95.1% identity with the rat ortholog, Kv6.3. The protein contains a pore forming domain and 6 transmembrane domains. RT-PCR analysis demonstrated high expression of human Kv6.3 in various regions of the brain. RT-PCR analysis in rat demonstrated that Kv6.3 is specifically expressed in neuronal cells.