Potassium Voltage Gated Channel Subfamily H, Member 6 (KCNH6)

KCNH6 belongs to the ERG subfamily of voltage-gated potassium channels. ERG channels are characterized by their anomalous gating behavior, with inactivation kinetics being faster than activation kinetics and with recovery from inactivation being faster than deactivation.The human KCNH6 gene, which they called HERG2, had been cloned. Rat Erg1 (KCNH2), Erg2, and Erg3 (KCNH7) were expressed throughout the brain, including the olfactory bulb, cerebral cortex, hippocampus, hypothalamus, and cerebellum. The kinetics of rat Erg2 expressed in Chinese hamster ovary cells. The time constant for deactivation was voltage dependent and decreased with more negative potentials. The deactivation kinetics of Erg2 and Erg1 were similar, but were significantly slower than those of Erg3.