Potassium Voltage Gated Channel Subfamily H, Member 7 (KCNH7)

KCNH7 belongs to the ERG subfamily of voltage-gated potassium channels. ERG channels are characterized by their anomalous gating behavior, with inactivation kinetics being faster than activation kinetics and with recovery from inactivation being faster than deactivation.The human KCNH7 gene, which they called HERG3, had been cloned. Using RT-PCR, they detected expression of HERG3 in prolactin-secreting adenomas. Rat Erg1 (KCNH2), Erg2 (KCNH6), and Erg3 were expressed throughout the brain, including the olfactory bulb, cerebral cortex, hippocampus, hypothalamus, and cerebellum.The time constant for deactivation was voltage dependent and decreased with more negative potentials. The deactivation kinetics of Erg3 were significantly faster than those of Erg1 and Erg2.