Prefoldin Subunit 6 (PFDN6)

Prefoldin is a family of proteins used in protein folding complexes. It is classified as a heterohexameric molecular chaperone in both archaea and eukarya, including humans. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins. A number of diseases are influenced by genes at the centromeric end of the major histocompatibility complex on 6p21.3. Herberg et al. (1998) cloned and characterized genes, including HKE2, in the 70-kb, gene-dense segment flanking the tapasin (TAPBP) gene. The 129-amino acid HKE2 protein is identical to the mouse Ke2 sequence apart from the insertion of 2 residues at position 122. Genomic sequence analysis determined that the gene contains 4 exons.