Proline Rich Nuclear Receptor Coactivator 1 (PNRC1)

Proline-rich nuclear receptor coactivator 1 is a protein encoded by the PNRC1 gene.By screening a natural killer (NK) cell cDNA library subtracted with a Jurkat T-cell line, Chen et al. (1995) obtained a cDNA encoding PROL2, which they termed B4-2. The deduced 327-amino acid proline-rich protein has a potential N-terminal SH3-binding domain, a nuclear targeting sequence, and 7 SPxx or TPxx motifs. Northern blot analysis revealed expression of a 1.9-kb transcript in NK, T, and monocyte cell lines, as well as in a variety of other cell lines. Western blot analysis showed expression of a 35-kD protein. The International Radiation Hybrid Mapping Consortium mapped the PROL2 gene to chromosome 6.