Protein Inhibitor Of Activated STAT 2 (PIAS2)

PIAS2 encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.The authors found that the PIASX transcript is alternatively spliced to yield 2 protein isoforms, PIASX-alpha and PIASX-beta, that differ in their C-terminal regions. Like other members of the PIAS family, the predicted PIASX proteins contain a putative zinc-binding motif and a highly acidic region.mouse Piasx-beta has an N-terminal SAP domain, followed by a proline-rich region, a RING-like zinc finger domain, 2 nuclear localization signals, and a serine/threonine-rich C-terminal domain. Mouse Piasx-beta localized in the nucleus.