Protein Phosphatase, EF-Hand Calcium Binding Domain 1 (PPEF1)

PPEF1 encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. PPEF1 has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.PPEF has a coding region of 1,962 bp and 61.7% similarity at the protein level to rdgC. The predicted 653-amino acid protein sequence includes a protein phosphatase catalytic domain at amino acids 150 to 438 and 2 EF-hand calcium-binding domains at its carboxyl end.