RANBP2 Like And GRIP Domain Containing Protein 8 (RGPD8)

The sequence similarity between RANBP2 and RANBP2-alpha precisely ends at an exon-intron boundary of RANBP2. The partial RANBP2-alpha cDNA is 99% identical to a cDNA encoding BS63 (RGPD5) over 1913 nucleotides. The deduced RANBP2-alpha protein contains 755 amino acids. Northern blot analysis detected an 8-kb mRNA in a variety of tissues, and an additional 14-kb transcript was seen in pancreas and placenta.The RGPD genes resulted from duplications of a region of human chromosome 2 containing the RANBP2 and GCC2 genes. Like other RGPD proteins, the deduced RGPD8 protein exceeds 1,700 amino acids. Most of the sequence is homologous to regions of RANBP2, except for the C terminus, which includes the GRIP domain from GCC2. RGPD8 expression in testis and HeLa cell cDNA libraries.