RCC1 And BTB Domain Containing Protein 1 (RCBTB1)

RCBTB1 encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.The deduced 531-amino acid protein has a calculated molecular mass of about 58 kD. RCBTB1 contains an N-terminal RCC1 domain and a C-terminal BTB (broad complex-tramtrack-bric-a-brac) domain. The RCC1 domain has 6 intradomain repeats of about 42 to 53 residues. RCBTB1 shares 67% identity with CHC1L.