RIMS Binding Protein 3B (RIMBP3B)

Mittelstaedt and Schoch (2007) cloned mouse Rimbp3, and by database analysis, they identified 3 human RIMBP3 genes, RIMBP3, RIMBP3B, and RIMBP3C, which share 99% nucleotide identity. Each of the deduced human RIMBP3 proteins contains 1,639 amino acids and has a calculated molecular mass of 180 kD.The protein has a central SRC homology-3 (SH3) domain, followed by 2 tandem fibronectin-like 3 (FN3) domains, and 2 C-terminal SH3 domains.The N-terminal region is rich in arginine, glutamic acid, aspartic acid, serine, and proline. Quantitative real-time PCR of mouse tissues detected ubiquitous Rimbp3 expression, with the highest level in testis. Rimbp3 showed low uniform expression in all mouse brain regions examined and in embryonic mouse brain.