RNA Binding Motif Protein 3 (RBM3)

RBM3 is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The gene gave rise to alternatively spliced transcripts in a variety of human tissues. The longest open reading frame encodes a 157-amino acid protein with a predicted molecular weight of 17 kD. Its putative RNA-binding domain most closely resembles that of 2 previously characterized human RNA-binding proteins, YRRM, the gene which has been implicated in azoospermia, and a glycoprotein identified as an autoantigen.