RNA Binding Motif Protein 5 (RBM5)

The deduced 815-amino acid protein contains 2 RNA-binding motifs, a C2C2-type zinc finger motif, a C2H2-type zinc finger motif, and a bipartite nuclear signal. Northern blot analysis of multiple tissues detected expression of 7.4- and 3.5-kb transcripts in all tissues investigated. Although the RBM5 gene is located in a region considered critical for the development of lung cancer, Northern and Southern analyses of a number of lung cancer cell lines revealed no patterns of aberrant RBM5 expression.G15, in a region of chromosome 3p21.3 that is associated with a putative lung cancer tumor suppressor gene. The mouse ortholog is 97% identical on the protein level. Northern blot analysis detected wide expression in normal and lung cancer tissues and cell lines.