RNA Binding Protein S1, Serine Rich Domain (RNPS1)

RNPS1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein. RNPS1 protein has long stretches that are 100% identical to the mouse protein. RNPS1 has a long N-terminal ser-rich (SR) region; a 90-residue RNA recognition motif that contains RNP1 and RNP2 submotifs; an SR splicing protein motif; 2 arg-rich RNA-binding domains; and a C-terminal nuclear localization signal. Northern blot analysis revealed ubiquitous expression of a 2.4-kb RNPS1 transcript.