RUN And SH3 Domain Containing Protein 1 (RUSC1)

RUSC1 consisting of 11 exons, was mapped to human chromosome 1q22. RUSC2 gene, consisting of 12 exons was mapped to human chromosome 9p13. Human RUSC1 gene as well as mouse Rusc1 gene were found to encode two isoforms with or without 411-bp exon 3 due to alternative splicing of exon-skipping type. RUSC1 and RUSC2 showed 30.5% total amino-acid identity. Human RUSC1, RUSC2, mouse Rusc1 and Rusc2 proteins were found to share the common domain structure, consisting of RUN, Leucine zipper, and SH3 domains. RUSC1, RUSC2, RIPX, RUFY1, RUFY2, RUTBC1, RUTBC2, RUTBC3, RUB6IP1, and PLEKHM1 were RUN domain proteins within the human proteome. This is the first report on comprehensive characterization of RUSC1 and RUSC2 orthologs.