Radical S Adenosyl Methionine Domain Containing Protein 1 (RSAD1)

The identification of the RSAD1 domain of Elp-3 as a breast cancer autoantigen is another example of the participation of antibody-recognized epitopes involved in protein-protein interactions, instrumental in epigenetic chromatin remodeling. Identical sequences have been cloned from colon carcinoma, chondrosarcoma, islets of Langerhans, lung cancer as well as from embryonic tissues. The association of Bmi-1 and RSAD1 on the autoantigen microarray could be a clue indicating that Bmi-1 might influence the set of reactions catalised by RSAD1. Purification of chromatin-associated hyperphophorylated RNAPII from yeast led to the isolation of the elongator multisubunit complex. The histone acetyltransferases and methyltransferases are part of a class of chromatin remodeling complexes that catalyze posttranslational histone acetylation and methylation reactions.