Ral Guanine Nucleotide Dissociation Stimulator Like Protein 1 (RGL1)

Ral guanine nucleotide dissociation stimulator (RALGDS) and its family members are involved in Ras and Ral signaling pathways as downstream effector proteins.The deduced 803-amino acid brain isoform, which is identical to the KIAA0959 protein isolated by Nagase et al. (1999), differs from the 768-amino acid liver isoform due to the substitution of 44 residues for the first 9 residues of the liver protein. The divergence results from the use of alternative first exons. Exon-trap and sequence analyses determined that the RGL gene contains 18 exons. The proteins both contain a CDC25 -like domain and a Ras-interacting domain. Northern blot analysis revealed ubiquitous expression of a 5.0-kb transcript, with an additional 5.3-kb transcript in brain.