Ras And Rab Interactor 2 (RIN2)

RIN2 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The deduced 895-amino acid protein contains an SH2 domain, 2 proline-rich domains, a RIN homology (RH) domain, a Vps9 domain, and a Ras association domain, and has a molecular mass of 116 kD. Northern blot analysis detected a 5.1-kb transcript in most tissues examined, with highest expression in heart and kidney, and lowest expression in spleen and peripheral blood cells.RIN2 mRNA expression was detected in HeLa and astrocytoma cell lines, but not in the Jurkat or THP1 leukemic cell linesRIN2 self-interacts as a homophilic tetramer that is formed by antiparallel linkage of 2 parallel dimers.