Ras Association Domain Containing Protein 7 (RASSF7)

An HRC1 cDNA probe recognized fragments on Southern blots of DNA from other vertebrate species. In human DNA, multiple homologous fragments were detected in addition to the predicted ones containing HRC1. HRC1 expression was upregulated with HRAS1 in a bladder carcinoma cell line, suggesting coordinate regulation. The deduced 373-amino acid protein contains regions rich in glutamine and proline and a region similar to the helix-loop-helix motif adjacent to a C-terminal leucine zipper dimerization motif with 4 heptad repeats. HRC1 contains a cluster of 2, and possibly 3, genes associated with CpG islands within the 32 kb immediately upstream of HRAS1. One of these loci, located 29 kb upstream of HRAS1 and provisionally designated HRC1, is divergently transcribed.