Regulator Of G Protein Signaling 20 (RGS20)

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.The deduced 218-amino acid sequence has a calculated molecular mass of about 25 kD. It contains a cysteine string that is a potential site for multiple palmitoylation N-terminal to its RGS box. RGSZ1 lacks the 156-residue N-terminal extension found in the related bovine retinal protein Ret-Rgs1. RGSZ1 shares 58% identity with GAIP (RGS19). Northern blot analysis revealed a 1.7-kb transcript expressed exclusively in brain, with highest levels in the caudate nucleus and temporal lobe.