Regulator Of G Protein Signaling 8 (RGS8)

Regulator of G-protein signaling 8 is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.Northern blot analysis revealed a 6.5-kb transcript expressed only in brain. Dot blot analysis of mRNA showed expression was stronger in several subregions of the brain, particularly pons, putamen, thalamus, caudate nucleus, and cerebellum. Low-level expression was detected in fetal brain, testis, and thyroid gland.