Regulatory Associated Protein Of mTOR (RPTOR)

RPTOR encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.RAPTOR has a positive role in nutrient-stimulated signaling to the downstream effector S6K1, maintenance of cell size, and MTOR protein expression. The association of RAPTOR with MTOR also negatively regulates the MTOR kinase activity.