Required For Meiotic Nuclear Division 5B (RMND5B)

RMND5B has a zinc finger domain and is highly conserved throughout many eukaryotic organisms. Two domains were predicted by the program BLIMPS to exist in the protein of which one of the domains contains a zinc finger domain. Zinc finger domains assist the binding of the protein to nucleic acids. This points to a direct interaction of CAD28476 with DNA during meiosis. By comparing CAD28476 with a related zinc finger protein in a local sequence alingment using LALIGN , the amino acids His359, Cys381 and Cys384 could be attributed to the zinc finger domain. This zinc finger structure is uncommon in the way that it involves one histidine instead of two. Microarray data show that CAD28476 is highly expressed in tissue where meiosis occurs like in testis and ovaries.