Ret Finger Protein Like Protein 2 (RFPL2)

The deduced 288-amino acid RFPL2 protein is 91 to 94% identical to RFPL1 and RFPL3. Exon 1 of RFPL2 encodes a putative RING-like motif, and exon 2 encodes a B30-2 domain. Northern blot analysis revealed expression of a 1.5-kb transcript that was abundant in prostate and less abundant in adult brain, fetal liver, and fetal kidney. A 1.2-kb transcript strongly expressed in testis and a 6-kb transcript strongly expressed in adult and fetal brain appeared to represent RFPL3S and RFPL1S, respectively.The human RFPL1, RFPL2, and RFPL3 genes are transactivated by the corticogenic transcription factor PAX6. Real-time PCR demonstrated that RFPL1,2,3 are highly expressed in embryonic stem cell-derived neurogenesis and in fetal neocortex.