Retinoic Acid Early Transcript 1G (RAET1G)

Members of the RAET1 family, such as RAET1G, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G differ from the other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences.The deduced 293-amino acid protein contains alpha-1 and alpha-2 domains, a transmembrane domain, and a 100-residue cytoplasmic tail containing a proline-rich SH3 kinase-binding motif. The RAET1G protein is 85% similar to ULBP2. Bacon et al. (2004) also identified a RAET1G splice variant with a 100-bp deletion at the start of exon 4, resulting in a truncated soluble protein.