Rho Guanine Nucleotide Exchange Factor 39 (ARHGEF39)

C9orf100 Contains 1 DH (DBL-homology) domain.Contains 1 PH domain.The PH domain family is very divergent at a sequence level, the average pairwise identity is below 20%. Despite this it is structurally very conserved with the core secondary structure superimposing well and almost all variation confined to the loops. Generall, one would need a higher identity between such small proteins to be confident about structural homology predictions and this remarkable structural conservation is one of the interesting features of this domain. Most PH domains have an electrostatic polarization similar to the experimental structures. However, roughly half of the PH domains linked to a Dbl-homology (DH) domain have very different electrostatic properties.