Rho Related BTB Domain Containing Protein 3 (RHOBTB3)

RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs. The C-terminal domain consists of about 80 amino acids in 4 consecutive alpha helices, with the last third having a high content of charged residues. RHOBTB3 ends in a prenylation motif not found in RHOBTB1 and RHOBTB2. RHOBTB3 shares 88% nucleotide identity with mouse Rhobtb3. Northern dot blot analysis revealed ubiquitous expression of RHOBTB3, with highest levels in placenta, testis, pancreas, adrenal and salivary gland, and neural and cardiac tissue. RHOBTB3 was also expressed in fetal tissues, particularly brain, heart, and lung. Northern blot analysis of mouse tissues revealed ubiquitous expression, with highest levels in brain, heart, and uterus.