Ribosomal Protein L13 (RPL13)

RPL13 encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast. The protein deduced from the nucleotide sequence was highly basic with no signal or transmembrane sequence, but 2 potential nuclear localization signals. The cDNA hybridized to multiple sequences within both human and other mammalian genomes and to single genomic sequences in Drosophila, Physarum, and Schizosaccharomyces pombe. Thus the cDNA represents a highly conserved gene sequence. Only 1 major transcript was identified in human cells, but the existence of several pseudogenes was suspected.