Ribosomal Protein L23A (RPL23A)

RPL23A may be one of the target molecules involved in mediating growth inhibition by interferon.This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.RPL23A transcript was more abundant in pancreas, skeletal muscle, and heart, while much less abundant in kidney, brain, placenta, lung, and liver. The open reading frame encodes a polypeptide of 156 amino acids, which is identical with the rat RPL23A protein. In the 5-prime flanking region of the gene, a canonical TATA sequence and a defined CAAT box were found for the first time in a mammalian ribosomal protein gene.