Ribosomal Protein L27 (RPL27)

RPL27 encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. The deduced 135-amino acid protein has a calculated molecular mass of about 18 kD. RPL27 shares 100% amino acid identity with rat and chicken Rpl27, although there are several silent base pair changes at the DNA level. Northern blot analysis revealed expression of a 1.0-kb transcript or 2 transcripts of 1.0 and 1.25 kb in fetal kidney. The 1.0-kb transcript was present at lower levels in adult kidney. RPL27 expression was also detected in several other fetal tissues, including muscle, liver, lung, heart, and brain.