Ribosomal Protein L27A (RPL27A)

RPL27A is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome.The deduced 148-amino acid human RPL27A differs from rat Rpl27a by 3 amino acids. Northern blot analysis suggested variable expression of RPL27A in colorectal cancers compared to adjacent normal tissues, although no correlation between the level of expression and the severity of the disease was found.