Ribosomal Protein S10 (RPS10)

RPS10 encodes a ribosomal protein that is a component of the 40S subunit. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. The deduced 165-amino acid human RPS10 differs from rat Rps10 by 2 amino acids; neither protein contains cysteine residues.RPS10 is necessary for production of the small subunit. RNA blot analysis showed accumulation of 43S, 26S, and 18S-E pre-rRNAs, consistent with defects in cleavage at both ends of the 18S rRNA.