Ribosomal Protein S27 Like Protein (RPS27L)

RPS27L shares 96.3% amino acid identity with RPS27. Expression of RPS27L was detected in most human tissues and human cancer cell lines examined.Gel retardation and chromatin immunoprecipitation assays showed that p53 bound to a putative p53-binding site in RPS27L intron 1. p53 activated transcription of a reporter gene driven by the RPS27L intron 1 sequence, and etoposide, a DNA-damaging agent that upregulates p53 expression, increased expression of the reporter gene. RPS27L expression promoted apoptosis following etoposide exposure, whereas small interfering RNA against RPS27L inhibited etoposide-induced apoptosis. p53 induces expression of RPS27L, which in turn promotes apoptosis.