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Артикул
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Наименование |
Производитель
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| E-AB-67763 |
E-AB-67763
RFFL Polyclonal Antibody
Источник (хозяин): кролик
Реактивность подтвержденная: человек, мышь, крыса
Валидировано для:
WB
Производитель:Elabscience
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Elabscience |
Rififylin (RFFL)
Английские синонимы
RNF189; RNF34L; Fring; Ring Finger And FYVE-Like Domain Containing 1; E3 ubiquitin-protein ligase rififylin; Caspases-8 and -10-associated RING finger protein 2
The mouse Rffl cDNA encodes 2 proteins of 336 and 364 amino acids, generated by alternative splicing. The N-terminal region contains a domain related to the FYVE double zinc finger domain that mediates binding to phosphatidylinositol 3-phosphate (PIK3), and the C-terminal region contains a consensus sequence for a C3HC4 RING finger domain.Northern blot analysis revealed a ubiquitously expressed transcript of approximately 4 kb and a smaller transcript of about 2 kb at a very high level in testis and at a moderate level in liver. RT-PCR indicated that both proteins are ubiquitously expressed, with the larger isoform almost exclusively expressed in adult mouse liver and kidney cells and in HeLa cells.
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