Ring Finger And CCCH-Type Zinc Finger Domains Protein 1 (RC3H1)

The roquin protein is distinguished by the presence of a CCCH zinc finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and stability.Roquin mRNA transcripts were found ubiquitously. The roquin protein is predicted to be a 1,130-residue intracellular protein highly conserved across its full length in mammals to invertebrates. The protein has an amino-terminal RING-1 zinc finger at residues 14-53 that conforms perfectly to the consensus for the E3 ubiquitin ligase family of proteins. Carboxy-terminal to the RING finger (residues 131-360) is a highly conserved novel protein domain (ROQ domain). A zinc finger domain of the C-X8-C-X5-C-X3-H type (CCCH type) occurs in the middle of roquin (residues 419-438).